Yes, this is a real Spider-Man lizard and not a computer-generated model. It's called the Mwanza Flat-headed Agama (Agama mwanzae), and it's a lizard in the family Agamidae found mainly in Tanzania, Rwanda, and Kenya. Continue reading for a video, more pictures, and additional information.
This species lives in semi-deserts and can often be seen in the heat of the day basking on rocks or kopjes. The male's head, neck and shoulders are bright red or violet, while the body is dark blue. The female is mostly brown and is difficult to distinguish from female agamas of other species. This lizard is often confused with the Red-headed Rock Agama (Agama agama).