Nintendo demonstrated Metroid Prime 3: Corruption for the Wii at E3 2006. It will utilize the Wiimote as expected. Video after the jump. Read a short summary below:
The war initiated by Dark Samus and the Space Pirates rages across many planets as they attempt to corrupt each with Phazon seeds. Players use the Wii Remote and Nunchuk to explore alien landscapes, hunt for weapons and information, and destroy the seeds. Saving the planets from Corruption isn’t enough, though. Eventually players must take down Samus’ mortal enemy’ Dark Samus.