You’ve seen DOOM running on a keycap, but what about E. Coli cells? PhD student Lauren Ramlan wanted to find out if it was possible. Put simply, this would require the cells to function as pixels, or a simple 1-bit black-and-white display where a pixel is either on or off, represented as 1 and 0 respectively.
The system would consist of cells contained within a 32×48 well plate connected to a display controller that processes the graphics output of DOOM and then translates the binary arrays into the addition or omission of a repressor controlling the fluorescence of the cells in that well. Theoretically, the output of this model would enable one to determine the frame rate at which DOOM could be displayed on E. Coli cells.
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The genetic system that I will be modeling is based on an inducer from the Registry of Standard Biological Parts, BBa_K3893028. This plasmid, designed for E. coli, contains two interacting genetic circuits,” said Ramlan.
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