Scientists using a high-tech microscope have captured real-time an immune cell migrating through the inner ear of a tiny zebrafish for the first time ev er. The blue dots are particles of dextran, a sugary polysaccharide that’s found in many substances, being swallowed by the immune cell. This experiment was led by Physicist Tsung-Li Liu’s team of researcher who combined two different imaging techniques into a hybrid that allows them to study a variety of delicate subcellular events in vivo.
This new hybrid technique combines lattice light-sheet microscopy (LLSM) with adaptive optics (AO) to create a system that can capture 3D ‘movies’ of specific structures in vivo at an unprecedented level of detail.
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This raises the nagging doubt that we are not seeing cells in their native state, happily ensconced in the organism in which they evolved. This also contributes to our fear that we are not seeing cells in their natural, unstressed form,” said Eric Betzig, team leader and physicist from the Howard Hughes Medical Institute in Virginia.
